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Advances of 12th CAPS research symposium: young chemists and chemical engineers fronts
Guoping Hu, Baiqian Dai
《化学科学与工程前沿（英文）》 2021年 第15卷 第3期 页码 461-463 doi: 10.1007/s11705-020-2026-6
Introduction to the special section on the 12
Zhen-Min CHENG
《化学科学与工程前沿（英文）》 2009年 第3卷 第1期 页码 1-1 doi: 10.1007/s11705-009-0003-1
ThMn12型永磁合金 Review
G.C. Hadjipanayis, A.M. Gabay, A.M. Schönhöbel, A. Martín-Cid, J.M. Barandiaran, D. Niarchos
《工程（英文）》 2020年 第6卷 第2期 页码 140-146 doi: 10.1016/j.eng.2018.12.011
具有四方ThMn12型结构的富铁化合物有潜力满足当下人们对于高磁能积、工作温度为150~200 ℃的贫稀土永磁体的需求。尽管磁体制备技术的发展滞后于相关磁性材料的研究是正常的，但对于ThMn12型磁性材料而言，这种研究进展的差异非常显著。人们发现，引入镧（La）可以提高Sm(Fe,Ti)12中少数低熔点相的稳定性，从而首次使得液相烧结成为可能。然而，La金属的高反应活性会明显地破坏材料的矫顽力（Hc）。,Sm)(Fe,Ti)12合金中也可以实现。机械化学合成的(Sm,Zr)(Fe,Si)12和(Sm,Zr)(Fe,Co,Ti)12粉末可能适合烧结成具有高强度的全致密磁体，尽管在此之前，两者都已开发出较高的各向异性
关键词： 永磁体，稀土永磁体，ThMn 12 结构
Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12
Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang
《医学前沿（英文）》 2019年 第13卷 第1期 页码 83-93 doi: 10.1007/s11684-019-0682-z
Colorectal cancer (CRC) is a common malignant tumor in the digestive tract, and 30%–85% of CRCs express epidermal growth factor receptors (EGFRs). Recently, treatments using cetuximab, also named C225, an anti-EGFR monoclonal antibody, for CRC have been demonstrated to cause an S492R mutation in EGFR. However, little is known about the biological function of S492R EGFR. Therefore, we attempted to elucidate its biological function in CRC cells and explore new treatment strategies for this mutant form. Our study indicated that EGFR and S492R EGFR accelerate the growth of CRC cells in vitro and in vivo and monoclonal antibody CH12, which specifically recognizes an EGFR tumor-specific epitope, can bind efficiently to S492R EGFR. Furthermore, mAb CH12 showed significantly stronger growth suppression activities and induced a more potent antibody-dependent cellular cytotoxicity effect on CRC cells bearing S492R EGFR than mAb C225. mAb CH12 obviously suppressed the growth of CRC xenografts with S492R EGFR mutations in vivo. Thus, mAb CH12 may be a promising therapeutic agent in treating patients with CRC bearing an S492R EGFR mutation.
关键词： S492R EGFR ectodomain mutation colorectal cancer mAb CH12 immunnotherapy
张果虎,肖清华,马飞
《中国工程科学》 2023年 第25卷 第1期 页码 68-78 doi: 10.15302/J-SSCAE-2023.01.002
Cehuang FU, Shuiyun SHEN, Ruofei WU, Xiaohui YAN, Guofeng XIA, Junliang ZHANG
《能源前沿（英文）》 2022年 第16卷 第4期 页码 607-612 doi: 10.1007/s11708-021-0798-0
关键词： Li4Ti5O12 phenolic-resin-based carbon mesoporous composite graphene
Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients
null
《医学前沿（英文）》 2017年 第11卷 第1期 页码 53-61 doi: 10.1007/s11684-017-0502-2
Low adherence to secondary prevention medications (ATM) of patients after acute coronary syndrome (ACS) is associated with poor clinical outcomes. However, literature provides limited data on assessment of ATM and risks associated with poor in Chinese patients with ACS. In the current work, ATM was assessed in consecutively recruited patients with ACS in Tongji Hospital from November 5, 2013 to December 31, 2014. A total of 2126 patients were classified under low adherence (proportion of days covered (PDC)<50%) and high adherence (PDC>50%) groups based on their performance after discharge. All patients were followed up at the 1st, 6th, and 12th month of discharge while recording ATM and major adverse cardiac events (MACE). Bivariate logistic regression was used to identify the factors associated with ATM. Cox regression was used to analyze the association between ATM and MACE within one year after discharge. Results showed that coronary artery bypass grafting (CABG) alone had significantly lower proportion of high adherence to P2Y12 antagonists (83.0% vs. 90.7%, P<0.01) than patients treated with percutaneous coronary intervention (PCI) only. Moreover, in patients undergoing PCI, high adherence to P2Y12 antagonists decreased the risk of MACE (hazard ratio=0.172, 95% confidence interval: 0.039–0.763; P=0.021). In conclusion, PCI-treated patients are more prone to remaining adherent to medications than CABG-treated patients. High adherence to P2Y12 antagonists was associated with lower risk of MACE.
关键词： acute coronary syndromes adherence to secondary prevention medications clinical outcome
利用基因组特异性引物和Cas12a介导技术快速检测稻瘟菌小麦致病型 Article
康厚祥, 彭烨, Kangyu Hua, 邓雨飞, Maria Bellizzi, Dipali Rani Gupta, Nur Uddin Mahmud, Alfredo S. Urashima, Sanjoy Kumar Paul, Gary Peterson, 周益林, 周雪平, Md Tofazzal Islam, 王国梁
《工程（英文）》 2021年 第7卷 第9期 页码 1326-1335 doi: 10.1016/j.eng.2020.07.016
Function of Slit/Robo signaling in breast cancer
null
《医学前沿（英文）》 2015年 第9卷 第4期 页码 431-436 doi: 10.1007/s11684-015-0416-9
Slit and Robo are considered tumor suppressors because they are frequently inactivated in various tumor tissue. These genes are closely correlated with CpG hypermethylation in their promoters. The Slit/Robo signaling pathway is reportedly involved in breast cancer development and metastasis. Overexpression of Slit/Robo induces its tumor suppressive effects possibly by inactivating the β-catenin/LEF/TCF and PI3K/Akt signaling pathways or by altering β-catenin/E-cadherin-mediated cell-cell adhesion in breast cancer cells. Furthermore, loss of Slit proteins or their Robo receptors upregulates the CXCL12/CXCR4 signaling axis in human breast carcinoma. In addition, this pathway regulates the distant migration of breast cancer cells not only by mediating the phosphorylation of the downstream molecules of CXCL12/CXCR4 and srGAPs, such as PI3K/Src, RAFTK/ Pyk2, and CDC42, but also by regulating the activities of MAP kinases. This review includes recent studies on the functions of Slit/Robo signaling in breast cancer and its molecular mechanisms.
关键词： Slit/Robo hypermethylation β-catenin CXCL12/CXCR4 migration
脚本学习综述 Review
韩毅1,乔林波1,郑建明2,吴贺丰3,李东升1,廖湘科1
《信息与电子工程前沿（英文）》 2021年 第22卷 第3期 页码 287-436 doi: 10.1631/FITEE.2000347
time constraints: declarative modeling approach
Izabela NIELSEN,Robert WÓJCIK,Grzegorz BOCEWICZ,Zbigniew BANASZAK
《信息与电子工程前沿（英文）》 2016年 第17卷 第4期 页码 338-347 doi: 10.1631/FITEE.1500359
关键词： Automated guided vehicles (AGVs) Scheduling Multimodal process Fuzzy constraints Optimization
一种基于卷积神经网络从3导联心电图推导标准12导联心电图的新方法 Regular Papers
Lu-di WANG, Wei ZHOU, Ying XING, Na LIU, Mahmood MOVAHEDIPOUR, Xiao-guang ZHOU
《信息与电子工程前沿（英文）》 2019年 第20卷 第3期 页码 405-413 doi: 10.1631/FITEE.1700413
700 °C 及以上蒸汽温度下先进USC发电厂用耐热材料的研究和开发 Review
Fujio Abe
《工程（英文）》 2015年 第1卷 第2期 页码 211-224 doi: 10.15302/J-ENG-2015031
关键词： 镍基合金 9 %~12 % Cr 钢 蠕变强度 蠕变疲劳性质 焊缝 晶界 显微结构 &gamma &prime M23C6 碳化物
R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome
《医学前沿（英文）》 2022年 第16卷 第6期 页码 932-945 doi: 10.1007/s11684-022-0963-9
关键词： Gitelman syndrome mouse model compound heterozygous hypokalemia Slc12a3
标题 作者 时间 类型 操作
Advances of 12th CAPS research symposium: young chemists and chemical engineers fronts
Guoping Hu, Baiqian Dai
期刊论文
ThMn12型永磁合金
G.C. Hadjipanayis, A.M. Gabay, A.M. Schönhöbel, A. Martín-Cid, J.M. Barandiaran, D. Niarchos
期刊论文
Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12
Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang
期刊论文
Facile controlled synthesis of hierarchically structured mesoporous Li4Ti5O12/C/rGO composites as high-performance
Cehuang FU, Shuiyun SHEN, Ruofei WU, Xiaohui YAN, Guofeng XIA, Junliang ZHANG
期刊论文
Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients
null
期刊论文
利用基因组特异性引物和Cas12a介导技术快速检测稻瘟菌小麦致病型
康厚祥, 彭烨, Kangyu Hua, 邓雨飞, Maria Bellizzi, Dipali Rani Gupta, Nur Uddin Mahmud, Alfredo S. Urashima, Sanjoy Kumar Paul, Gary Peterson, 周益林, 周雪平, Md Tofazzal Islam, 王国梁
期刊论文
time constraints: declarative modeling approach
Izabela NIELSEN,Robert WÓJCIK,Grzegorz BOCEWICZ,Zbigniew BANASZAK
期刊论文
一种基于卷积神经网络从3导联心电图推导标准12导联心电图的新方法
Lu-di WANG, Wei ZHOU, Ying XING, Na LIU, Mahmood MOVAHEDIPOUR, Xiao-guang ZHOU
期刊论文
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